Compound library
TB-500 (Thymosin β4 fragment)
The acetylated actin-binding fragment of thymosin β4.
MW 889.02 CAS 885340-08-9 ≥99.0% (HPLC)
The acetylated actin-binding fragment of thymosin β4.
What it is
TB-500 is a synthetic seven-residue peptide, Ac-LKKTETQ, corresponding to the central actin-binding region of thymosin β4, a 43-residue protein that sequesters monomeric G-actin and is abundant in most cells.
The full-length protein has been studied for its roles in cell migration, angiogenesis and wound repair. The 17–23 fragment is used in research to isolate the activity associated with this actin-binding motif in cell-migration and wound-healing models.
Note that TB-500 is the fragment, not full-length thymosin β4. Supplied as a lyophilized acetate salt.
Specifications
| Sequence | Ac Leu Lys Lys Thr Glu Thr Gln |
|---|---|
| Molecular formula | C38H68N10O14 |
| Molecular weight | 889.02 |
| CAS number | 885340-08-9 |
| Purity specification | ≥99.0% (HPLC) |
| Storage | −20 °C, sealed, protected from light |
How it is handled in the lab
Supplied lyophilized. Warm the sealed vial to room temperature before opening, reconstitute in a solvent suited to the sequence, and divide into single-use aliquots. See our Storage & Handling guide.